Chris Kettle

Congratulation Anouk!!!!



I went to Westlands High School in Congleton (Cheshire), then to Sheffield University to study Genetics and then to Newcastle Univeristy for my PhD


BSc (Hons) Genetics, PhD Evolutionary Developmental Genetics

Work History:

Here since I graduated

Current Job:

Clinical Cytogeneticist – a scientist who looks at chromosomes


Mr Cameron, via the NHS

Me and my work

Clinical Cytogenetics – the heart of genetics

Clinical cytogenetics is the study of chromosomes and the way that changes to their number and structure can lead to disease or disability.

The normal human has 46 chromosomes, 23 pairs: 22 autosomes (1-22) and the sex chromosomes, XX for female, XY for male.

A clinical cytogeneticist loks at the 23 pairs of chromosomes in an individual looking for losses, gains or rearrangements of the genetic material. This technique is called karyotyping. Traditionally this is done with stains that differentiate between areas that are gene-rich and those that are gene-poor. The stained, or banded, chromosomes are viewed used light microscopy – which has a minimum resolution of 5-10 Mega bases (Mb). A point of reference is that chromosome 21, where 3 copeis are seen in Down syndrome, is about 35-40Mb in length.

We can increase our resolution by asking specific questions with long strands of DNA which are attached to flurescent probes. This technique is called fluorescent in situ hybridiation (FISH) and can be used to look for single gene deletions. FISH is NOT a whole genome scan like karyotyping as the FISH probes are specific to particular streches of DNA within the genome.

A relatively new technique in cytogenetics is array comparative genome hybridisation (aCGH). In short, aCGH compares the patients genome with a normal control. This is a whole genome screen and at the end a “virtual” karyotype is examined. This technique provides so much data that it would be nearly impossible for a human to understand it and we need a superfast computer to process the results.

In the not too distant future though, I think that this kind of microscope work will be replaced by Star Trek-like scanners and the microscope will only be seen in the museum. If you want to see what I am talking about – just google New Generation Sequencing, or better still Quantum DX, a pocket-sized genome scanner.

My Typical Day

Currently I am rotating in the diagnosis and the prognosis in cancer.

Cancer cytogenetics is heavily dependent on the FISH I mention above. This looks for fusions between genes which should have been brought together. This reults in genes being turned on when they shouldn’t be and can lead to cancer.

I spend time looks for abnormal results for FISH. I also look at karyotypes to see if there is anything that FISH has missed or couldn’t detect.

What I really like is being able to give patients good news, telling them that “Ok, you have cancer but our work shows that you can be cured by this treatment”. Obviously there are bad days too when we have to give really bad news.

What I'd do with the money

I’d host science gameshows in several schools in the area.

None of the boring run-of-the-mill science competetitions where marks are given for those boring presnetations (*YAWN*).

I’d try to work with the schools to offer prizes for the student(s).

Catergories could include model making, pop-quizes, re-inacting famous discoveries etc.

Remember – SCIENCE IS FUN!

My Interview

How would you describe yourself in 3 words?

Happy, Clever, Witty.

Who is your favourite singer or band?

Gary Barlow- I grew up next door to him and we used to play together as kids.

What is the most fun thing you've done?

A fully interactive zombie experience in a supermarket – being chased by actors playing the role of zombies. Fun and frightening. I survived thankfully :)

If you had 3 wishes for yourself what would they be? - be honest!

1) I’d like to time travel. I am very nosey so I want to know what happens in the distant future. 2) Have a superhero power like flying or invisibility, & 3) be rich.

What did you want to be after you left school?

A forensic scientist. Those guys are the business.

Were you ever in trouble in at school?

Yes, most days. I only calmed down at GCSE level.

What's the best thing you've done as a scientist?

I found a centipede with an even number of pairs of legs (Nature, 1999)

Tell us a joke.

A plastic bag igoes to a Doctor’s surgery. The doctor looks at the the bag and says “I’m afraid you may have a genetic disease”, the bag looks shocked and asks how this could have happened. The doctor replies “Your mother was a carrier” :)

Other stuff

Work photos: