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Asked by nadiaeg to Chris on 19 Jun 2012.
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Chris Kettle answered on 19 Jun 2012:
FISH – fluoresent in situ hybridisation – is used to look at specific areas of the genome, looking for missing DNA, extra DNA or DNA that has moved from where it should be. This is possible as the FISH probe matches the target DNA sequence and binds to it wherever it is (and wont bind when its missing). The fluoresent bit allows a light to be seen on the chromosome and this shows us where the probe has stuck too.
I has let us discover lots of new diseases, usually where DNA is missing, for example HIRA and TBX in DiGeorge syndrome (google it 🙂 )
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Comments
xxheavymetalbadgerxx commented on :
It Is A Water Based Organism You Batter And Eat With Chips
Chris commented on :
xxheavymetalbadgerxx – thats quite funny. I haven’t heard that one in years. You get those jokes when you start off in the job but soon forget them – thanks for the chuckle.